Asymmetric Ion Pair Catalysis of 6π Electrocyclizations: Brønsted Acid Catalyzed Enantioselective Synthesis of Optically Active 1, 4‐Dihydropyridazines1. Issue 31 (20th June 2013)

• Record Type: Journal Article
• Authors: Das, Arindam; Volla, Chandra M. R.; Atodiresei, Iuliana; Bettray, Wolfgang; Rueping, Magnus
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 31(2013)
• Page Start: 8008
• Page End: 8011
• Publication Date: 2013-06-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201301638
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Electric slide</bold>: Described is a general, operationally simple, highly enantioselective Brønsted acid catalyzed condensation/6π‐electrocyclization reaction between hydrazones and α, β‐unsaturated aldehydes that yields valuable 1, 4‐dihydropyridazines. The reaction exhibits high tolerance towards functional groups and affords products with up to 98 % <italic>ee.</italic><boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg276x4fpm" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>