BODIPY–Tetrazine Derivatives as Superbright Bioorthogonal Turn‐on Probes1. Issue 27 (27th May 2013)

• Record Type: Journal Article
• Authors: Carlson, Jonathan C. T.; Meimetis, Labros G.; Hilderbrand, Scott A.; Weissleder, Ralph
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 27(2013)
• Page Start: 6917
• Page End: 6920
• Publication Date: 2013-05-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201301100
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The fastest and the brightest</bold>: A new design that intimately connects tetrazine to a BODIPY fluorophore enables exceptionally efficient energy transfer and quenching. Upon reaction of the tetrazine, the brightness of the fluorophore increases more than a thousand‐fold, which is a fluorogenic activation up to two orders of magnitude greater than previously described.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg22f1qq3x" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>