Synthesis of Unsymmetric Diphospho‐Inositol Polyphosphates1. Issue 27 (27th May 2013)

• Record Type: Journal Article
• Authors: Capolicchio, Samanta; Thakor, Divyeshsinh T.; Linden, Anthony; Jessen, Henning J.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 27(2013)
• Page Start: 6912
• Page End: 6916
• Publication Date: 2013-05-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201301092
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>One to rule them all</bold>: A novel <italic>C</italic>₂‐symmetric phosphoramidite was developed that can be used to prepare all four unsymmetric diphospho inositol pentaphosphates (PP‐InsP₅). The target structures were synthesized in few steps and high enantiomeric ratios. With the obtained compounds, specificity of Ddp1 from yeast (a PP‐InsP₅ phosphatase) was studied.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg22f1qq74" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>