Collagen‐like Cell‐Penetrating Peptides1. Issue 21 (16th April 2013)

• Record Type: Journal Article
• Authors: Yamazaki, Chisato M.; Nakase, Ikuhiko; Endo, Hiroyuki; Kishimoto, Saya; Mashiyama, Yoshihiro; Masuda, Ryo; Futaki, Shiroh; Koide, Takaki
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 21(2013)
• Page Start: 5497
• Page End: 5500
• Publication Date: 2013-04-16
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201301266
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Arginine‐rich</bold> heterotrimeric collagen‐like peptides were prepared, and their cellular uptake efficiency was evaluated. The spatial arrangement of the Arg residues (blue in picture) on the triple‐helix surface significantly affected the efficacy of the cellular uptake. The collagen‐like triple‐helical conformation provides these cell‐penetrating peptides with a high resistance to proteases. O=<sc>L</sc>‐4‐hydroxyproline.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1zsx7kfx" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>