Chiral Magnesium(II) Binaphtholates as Cooperative Brønsted/Lewis Acid–Base Catalysts for the Highly Enantioselective Addition of Phosphorus Nucleophiles to α, β‐Unsaturated Esters and Ketones1. Issue 17 (13th March 2013)

• Record Type: Journal Article
• Authors: Hatano, Manabu; Horibe, Takahiro; Ishihara, Kazuaki
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 17(2013)
• Page Start: 4549
• Page End: 4553
• Publication Date: 2013-03-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201300938
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A little cooperation goes a long way</bold>: The cooperative Brønsted/Lewis acid–base supramolecular catalysts formed in situ from simple chiral magnesium(II) binaphtholate aqua complexes promoted the highly enantioselective 1, 4‐hydrophosphinylation of α, β‐unsaturated esters with diaryl phosphine oxides and 1, 2‐hydrophosphonylation of α, β‐unsaturated ketones with dialkyl phosphites (see scheme).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1xps7sws" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>