Direct Synthesis of Pyrroles by Dehydrogenative Coupling of β‐Aminoalcohols with Secondary Alcohols Catalyzed by Ruthenium Pincer Complexes1. Issue 14 (6th March 2013)

• Record Type: Journal Article
• Authors: Srimani, Dipankar; Ben‐David, Yehoshoa; Milstein, David
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 14(2013)
• Page Start: 4012
• Page End: 4015
• Publication Date: 2013-03-06
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201300574
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Pyrroles</bold> were synthesized in one step by using the acceptorless dehydrogenative coupling of amino alcohols with secondary alcohols (equivalent amounts), catalyzed by ruthenium pincer complexes (0.5 mol %) and a base (less than stoichiometric amounts) through selective CN and CC bond formation. This atom‐economical, environmentally friendly methodology offers easy access to a range of substituted pyrroles in moderate to good yields.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1x47k7c8" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>