Synthesis of Epoxyisoprostanes: Effects in Reducing Secretion of Pro‐inflammatory Cytokines IL‐6 and IL‐121. Issue 20 (16th April 2013) - Egger, Julian
Abstract Anti‐inflammatory: The efficient and general synthetic route to the elusive epoxyisoprostanoid phospholipids PECPC and PEIPC, along with the isoprostanoids EC and EI, relies on a number of stereo‐ and chemoselective steps, including a CH insertion for the rapid construction of the cyclopentanone ring. The synthesized compounds display unprecedented biological activity in reducing the secretion of pro‐inflammatory cytokines.