Base‐Pairing Properties of a Structural Isomer of Glycerol Nucleic Acid1. Issue 22 (18th April 2013)

• Record Type: Journal Article
• Authors: Karri, Phaneendrasai; Punna, Venkateshwarlu; Kim, Keunsoo; Krishnamurthy, Ramanarayanan
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 22(2013)
• Page Start: 5840
• Page End: 5844
• Publication Date: 2013-04-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201300795
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Know your limit</bold>! IsoGNA (a structural isomer of GNA) was found—in sharp contrast to GNA—to be highly restricted in its ability to base‐pair with itself and other nucleic acids. While homogeneous sequences (e.g. isoGNA(A)₁₆) formed duplexes, the heterogeneous sequences showed no base‐pairing. This exemplifies the limitations of canonical nucleobases as the recognition elements in simpler, more primitive phosphate backbones.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg20p490nk" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>