Direct Deamination of Primary Amines by Water To Produce Alcohols1. Issue 24 (25th April 2013)

• Record Type: Journal Article
• Authors: Khusnutdinova, Julia R.; Ben‐David, Yehoshoa; Milstein, David
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 24(2013)
• Page Start: 6269
• Page End: 6272
• Publication Date: 2013-04-25
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201301000
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Just add water!</bold> The title reaction is catalyzed by an acridine‐based pincer complex (<bold>1</bold>, see scheme). This one‐step transformation uses water as the only reagent in the absence of additional bases, oxidants, or reductants. Cyclization of 1, 4‐diaminobutane and 1, 6‐diaminohexane catalyzed by <bold>1</bold> leads to the formation of pyrrolidine and azepane, respectively.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg21fg62xj" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>