Construction of Protein Nanowires through Cucurbit[8]uril‐based Highly Specific Host–Guest Interactions: An Approach to the Assembly of Functional Proteins1. Issue 21 (19th April 2013)

• Record Type: Journal Article
• Authors: Hou, Chunxi; Li, Jiaxi; Zhao, Linlu; Zhang, Wei; Luo, Quan; Dong, Zeyuan; Xu, Jiayun; Liu, Junqiu
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 21(2013)
• Page Start: 5590
• Page End: 5593
• Publication Date: 2013-04-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201300692
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Getting your proteins in a row</bold>: Self‐assembled protein nanowires were designed by utilizing highly specific supramolecular interactions of cucurbit[8]uril (CB[8]) and a tripeptide FGG‐tag attached on the N‐termini of dimeric glutathione S‐transferase (GST). With the aid of enzyme simulation, model protein GST was converted into a selenoenzyme glutathione peroxidase mimic, and the CB[8]‐induced Se‐FGG‐GST(Y6C) nanowires demonstrated excellent antioxidative capacity.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1zsx7rdz" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>