Quantum Chemistry as a Tool in Asymmetric Biocatalysis: Limonene Epoxide Hydrolase Test Case1. Issue 17 (19th March 2013)

• Record Type: Journal Article
• Authors: Lind, Maria E. S.; Himo, Fahmi
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 17(2013)
• Page Start: 4563
• Page End: 4567
• Publication Date: 2013-03-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201300594
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Cluster model</bold>: Large active‐site models (see figure) are used to investigate the selectivity of limonene epoxide hydrolase, both the wild type and mutants optimized through directed evolution. Good agreement is found between theory and the experimental data, thus demonstrating that the quantum chemical cluster approach can be a powerful tool in the field of asymmetric biocatalysis.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1xps7vj9" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>