Identification of Cystathionine β‐Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe1. Issue 17 (19th March 2013)

• Record Type: Journal Article
• Authors: Thorson, Megan K.; Majtan, Tomas; Kraus, Jan P.; Barrios, Amy M.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 17(2013)
• Page Start: 4641
• Page End: 4644
• Publication Date: 2013-03-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201300841
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Buzzing with activity</bold>: A hydrogen sulfide selective fluorogenic probe, 7‐azido‐4‐methylcoumarin (AzMC), serves as a highly sensitive assay for cystathionine β‐synthase activity, and is suitable for the high‐throughput discovery of novel enzyme inhibitors.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1xps7pvp" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>