Red‐Light‐Controlled Protein–RNA Crosslinking with a Genetically Encoded Furan1. Issue 17 (19th March 2013)

• Record Type: Journal Article
• Authors: Schmidt, Moritz J.; Summerer, Daniel
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 17(2013)
• Page Start: 4690
• Page End: 4693
• Publication Date: 2013-03-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201300754
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Well red</bold>: A protein‐RNA crosslinker has been genetically encoded that can be controlled with red light (see scheme), thus offering high penetration depths in biological materials. This should enable the discovery and mapping of transient protein–RNA interactions and enable the design of peptide‐ and protein‐based drugs for RNA‐targeted photodynamic therapy.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1xps7rzc" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>