Acid‐Catalyzed In Situ Generation of Less Accessible or Unprecedented N‐Boc Imines from N‐Boc Aminals1. Issue 21 (15th April 2013)

• Record Type: Journal Article
• Authors: Kano, Taichi; Yurino, Taiga; Asakawa, Daisuke; Maruoka, Keiji
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 21(2013)
• Page Start: 5532
• Page End: 5534
• Publication Date: 2013-04-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201300231
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Crafty aminals</bold>: The in situ generation of hitherto unattainable alkynyl‐substituted <italic>N</italic>‐Boc‐protected imines was realized by the acid‐catalyzed elimination of <italic>tert</italic>‐butyl carbamate from <italic>N</italic>‐Boc aminals. A wide variety of <italic>N</italic>‐Boc imines can be generated, which can then be utilized for subsequent carbon–carbon bond‐forming reactions, such as Mannich‐type reactions.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1zsx7cz3" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>