Inside Back Cover: Discovery of Hepatitis C Virus NS3 Helicase Inhibitors by a Multiplexed, High‐Throughput Helicase Activity Assay Based on Graphene Oxide (Angew. Chem. Int. Ed. 8/2013). Issue 8 (28th January 2013)

• Record Type: Journal Article
• Authors: Jang, Hongje; Ryoo, Soo‐Ryoon; Kim, Young‐Kwan; Yoon, Soojin; Kim, Henna; Han, Sang Woo; Choi, Byong‐Seok; Kim, Dong‐Eun; Min, Dal‐Hee
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 8(2013)
• Page Start: 2373
• Page End: 2373
• Publication Date: 2013-01-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201300345
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>DNA helicases are important targets for anti‐viral drug development. In their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 2340 ff., </ext-link> D.‐H. Min et al. use graphene oxide for high‐throughput chemical screening to discover new inhibitors of two different helicases derived from hepatitis C virus and severe acute respiratory syndrome (SARS) coronavirus in a multiplexed assay. The developed assay can also be used to validate hits from the helicase inhibitor screen.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1xm2h0c7" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>