Catalytic Asymmetric Synthesis of Cyclic Ethers Containing an α‐Tetrasubstituted Stereocenter1. Issue 18 (8th April 2013)

• Record Type: Journal Article
• Authors: Cox, Nick; Uehling, Mycah R.; Haelsig, Karl T.; Lalic, Gojko
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 18(2013)
• Page Start: 4878
• Page End: 4882
• Publication Date: 2013-04-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201300174
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>'Ether' furan or pyran</bold>: The <italic>exo</italic>‐selective cyclization of enantioenriched allenols is accomplished with high chirality transfer using as little as 0.02 mol % of a gold catalyst. The new method is effective in the synthesis of a wide range of enantioenriched cyclic ethers, which are prepared in excellent yields in three steps from readily available propargylic phosphates.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1xpsz42v" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>