Aerobic Synthesis of Pyrroles and Dihydropyrroles from Imines: Palladium(II)‐Catalyzed Intramolecular CH Dehydrogenative Cyclization1. Issue 18 (8th April 2013)

• Record Type: Journal Article
• Authors: Shi, Zhuangzhi; Suri, Mamta; Glorius, Frank
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 18(2013)
• Page Start: 4892
• Page End: 4896
• Publication Date: 2013-04-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201300477
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>sp³ectacularly mild!</bold> An efficient Pd^II‐catalyzed intramolecular dehydrogenative cyclization of imines affords (dihydro)pyrrole products using molecular oxygen as the sole oxidant. This mild formal sp³‐CH functionalization allows rapid and atom‐economical assembly of (dihydro)pyrrole rings from inexpensive and readily available allylamines and ketones. A broad range of functional groups are tolerated.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1xpszgmv" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>