Sequence‐Controlled Multi‐Block Glycopolymers to Inhibit DC‐SIGN‐gp120 Binding1. Issue 16 (11th March 2013)

• Record Type: Journal Article
• Authors: Zhang, Qiang; Collins, Jennifer; Anastasaki, Athina; Wallis, Russell; Mitchell, Daniel A.; Becer, C. Remzi; Haddleton, David M.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 16(2013)
• Page Start: 4435
• Page End: 4439
• Publication Date: 2013-03-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201300068
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Chain of command</bold>: Multi‐block glycopolymers made of mannose (M, see figure), glucose, and di(ethylene glycol) ethyl ether (D) monomers were synthesized using a technique to control the polymer sequence. These highly monodisperse glycopolymers were then tested for binding and inhibition of DC‐SIGN, a protein important for HIV infection.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1xprgbw0" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>