Synthesis of Stable Peptide Nucleic Acid‐Modified Gold Nanoparticles and their Assembly onto Gold Surfaces1. Issue 15 (4th March 2013)

• Record Type: Journal Article
• Authors: Anstaett, Philipp; Zheng, Yuanhui; Thai, Thibaut; Funston, Alison M.; Bach, Udo; Gasser, Gilles
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 15(2013)
• Page Start: 4217
• Page End: 4220
• Publication Date: 2013-03-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201209684
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>PNA does it better:</bold> Peptide nucleic acid (PNA) oligomers were attached to gold nanoparticles (AuNPs) through a variety of mono‐ and trithiol linkers. These functionalized particles had sufficient stability for sequence‐specific self‐assembly onto gold surfaces (see figure) in the absence of ions or surfactants. The nanoparticle surface densities obtained were superior to comparable DNA‐modified AuNPs.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1x47f952" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>