A Soft Vinyl Enolization Approach to α‐Acylvinyl Anions: Direct Aldol/Aldol Condensation Reactions of (E)‐β‐Chlorovinyl Ketones1. Issue 13 (18th February 2013)

• Record Type: Journal Article
• Authors: Kim, Hun Young; Li, Jian‐Yuan; Oh, Kyungsoo
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 13(2013)
• Page Start: 3736
• Page End: 3740
• Publication Date: 2013-02-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201209876
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Synthesizing the synthons</bold>: The development of α‐acylvinyl anion synthons has been achieved using direct α‐vinyl enolization of α, β‐unsaturated ketones under mild reaction conditions. The synthetic utility of such synthons has been demonstrated in intermolecular aldol and aldol condensation reactions, which provide synthetically useful allenyl ketone and enyne derivatives.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1v8chwmp" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>