A Drug‐Delivery Vehicle Combining the Targeting and Thermal Ablation of HER2+ Breast‐Cancer Cells with Triggered Drug Release1. Issue 15 (11th March 2013)

• Record Type: Journal Article
• Authors: You, Jin‐Oh; Guo, Peng; Auguste, Debra T.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 15(2013)
• Page Start: 4141
• Page End: 4146
• Publication Date: 2013-03-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201209804
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Covering all three bases</bold>: Drug‐delivery vehicles that encapsulate doxorubicin (Dox) within a pH‐sensitive matrix embedded with gold nanoparticles were synthesized with Herceptin–poly(ethylene glycol) conjugates on the surface for the specific binding of cancer cells (see picture; NIR=near infrared). Cell targeting was combined with enhanced cytotoxicity through triggered drug release (at pH 5–6) and thermal ablation (a photothermal effect).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1x47g2c7" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>