Brønsted Acid Catalyzed Asymmetric SN2‐Type O‐Alkylations1. Issue 12 (10th February 2013) - Čorić, Ilija
Abstract Bridging the gap: Brønsted acids catalyze an intramolecular SN2‐type alkylation of alcohols with ethers by bridging a pentacoordinate transition state, thus simultaneously activating both the leaving group and nucleophile (see scheme). Density functional calculations provide detailed insight into the course of the reaction and the transition‐state structure.