A R2p/R1p Ratiometric Procedure to Assess Matrix Metalloproteinase‐2 Activity by Magnetic Resonance Imaging1. Issue 14 (28th February 2013)

• Record Type: Journal Article
• Authors: Catanzaro, Valeria; Gringeri, Concetta V.; Menchise, Valeria; Padovan, Sergio; Boffa, Cinzia; Dastrù, Walter; Chaabane, Linda; Digilio, Giuseppe; Aime, Silvio
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 14(2013)
• Page Start: 3926
• Page End: 3930
• Publication Date: 2013-02-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201209286
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Parametric MRI</bold>: A paramagnetic gadolinium‐loaded liposome for the MRI assessment of the activity of matrix metalloproteinase‐2 (MMP‐2) is described. The assessment relies on a procedure that involves the ratio <italic>R</italic>_2p/<italic>R</italic>_1p between the transverse and longitudinal paramagnetic contributions to the water proton relaxation rate. This method is independent of the total gadolinium concentration.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1x47k92b" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>