Chemical Interrogation of Drug/RNA Complexes: From Chemical Reactivity to Drug Design1. Issue 11 (7th February 2013)

• Record Type: Journal Article
• Authors: Jiménez‐Moreno, Ester; Gómez‐Pinto, Irene; Corzana, Francisco; Santana, Andrés G.; Revuelta, Julia; Bastida, Agatha; Jiménez‐Barbero, Jesus; González, Carlos; Asensio, Juan Luis
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 11(2013)
• Page Start: 3148
• Page End: 3151
• Publication Date: 2013-02-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201209434
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>When you're in a (RNA) bind</bold>: An NMR‐based method to explore the reactivity of ligand/RNA complexes can be used as source of valuable information for drug design. By combining NMR spectroscopy and a simple isotopic labeling strategy (see picture), positional chemical reactivity information can be readily extracted from complex aminoglycoside mixtures. C green, N blue, O red, Me purple.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1v8wstm7" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>