A Reactive Oxygen Species (ROS)‐Responsive Polymer for Safe, Efficient, and Targeted Gene Delivery in Cancer Cells1. Issue 27 (28th May 2013)

• Record Type: Journal Article
• Authors: Shim, Min Suk; Xia, Younan
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 27(2013)
• Page Start: 6926
• Page End: 6929
• Publication Date: 2013-05-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201209633
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Stimuli‐responsive release</bold>: The high levels of reactive oxygen species (ROS) in prostate cancer cells can be exploited to trigger cancer‐targeted gene delivery. A ROS‐responsive thioketal‐based cationic polymer was synthesized and functionalization with a cancer‐targeting peptide led to selective and enhanced gene transfection in prostate cancer cells (see scheme).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg22f1qx31" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>