Rhodium‐ and Platinum‐Catalyzed [4+3] Cycloaddition with Concomitant Indole Annulation: Synthesis of Cyclohepta[b]indoles1. Issue 11 (10th February 2013)

• Record Type: Journal Article
• Authors: Shu, Dongxu; Song, Wangze; Li, Xiaoxun; Tang, Weiping
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 11(2013)
• Page Start: 3237
• Page End: 3240
• Publication Date: 2013-02-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201209266
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Various substituted</bold> cyclohepta[<italic>b</italic>]indoles were prepared from propargylic ethers and dienes by a tandem indole annulation/[4+3] cycloaddition (see scheme; Boc=<italic>tert</italic>‐butoxycarbonyl). Both acyclic and cyclic dienes participated in the [4+3] cycloaddition to afford tri‐ and tetracyclic products, respectively. Electron‐deficient phosphine or phosphite ligands facilitated the tandem reaction.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1v8wsz54" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>