Effective Chiral Discrimination of Tetravalent Polyamines on the Compaction of Single DNA Molecules1. Issue 13 (25th February 2013)

• Record Type: Journal Article
• Authors: Yoshikawa, Yuko; Umezawa, Naoki; Imamura, Yuki; Kanbe, Toshio; Kato, Nobuki; Yoshikawa, Kenichi; Imanaka, Tadayuki; Higuchi, Tsunehiko
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 13(2013)
• Page Start: 3712
• Page End: 3716
• Publication Date: 2013-02-25
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201209144
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Normal doughnuts or lots of little ones?</bold> Among four stereoisomers of a tetravalent polyamine, the isomer pictured was the most potent at inducing DNA compaction, whereby the DNA molecules adopted a unique morphology of minitoroid clusters. The nonchiral polyamine spermine induced the formation of typical, larger toroidal structures.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1v8cj175" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>