The Flavoprotein Dodecin as a Redox Probe for Electron Transfer through DNA1. Issue 18 (26th March 2013)

• Record Type: Journal Article
• Authors: Yu, Yaming; Heidel, Björn; Parapugna, Tamara Lourdes; Wenderhold‐Reeb, Sabine; Song, Bo; Schönherr, Holger; Grininger, Martin; Nöll, Gilbert
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 18(2013)
• Page Start: 4950
• Page End: 4953
• Publication Date: 2013-03-26
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201208987
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Flavin away</bold>: Dodecin binds oxidized flavins, whereas reduction of the bound flavin induces dissociation of the holoprotein into apododecin and free flavins. The stepwise reconstitution of dodecin on flavin‐terminated ds‐DNA monolayers showed that although electrochemical flavin reduction (i.e. electron transfer through DNA) was not possible, apododecin (gray circles) could be released by chemical reduction (see scheme).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1xpsz2k3" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>