A Protein‐Interaction Array Inside a Living Cell1. Issue 18 (4th March 2013)

• Record Type: Journal Article
• Authors: Gandor, Silke; Reisewitz, Stephanie; Venkatachalapathy, Muthukumaran; Arrabito, Giuseppe; Reibner, Martina; Schröder, Hendrik; Ruf, Katharina; Niemeyer, Christof M.; Bastiaens, Philippe I. H.; Dehmelt, Leif
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 18(2013)
• Page Start: 4790
• Page End: 4794
• Publication Date: 2013-03-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201209127
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Taking the bait</bold>: Protein‐interaction arrays were generated in living cells by the interaction of bait‐presenting artificial receptor constructs (bait‐PARCs) with micrometer‐scaled antibody surface patterns (see figure). This method was applied to simultaneously monitor the interaction kinetics of a prey protein with two distinct bait proteins in individual living cells.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1xpszkcj" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>