Stoichiometric Leverage: Rapid 18F‐Aryltrifluoroborate Radiosynthesis at High Specific Activity for Click Conjugation1. Issue 8 (11th January 2013)

• Record Type: Journal Article
• Authors: Liu, Zhibo; Li, Ying; Lozada, Jerome; Schaffer, Paul; Adam, Michael J.; Ruth, Thomas J.; Perrin, David M.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 8(2013)
• Page Start: 2303
• Page End: 2307
• Publication Date: 2013-01-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201208551
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Raising the</bold> ^{<bold>18</bold>} <bold>F</bold> _{<bold>3</bold>} <bold>‐BAr</bold>: Specific activities of most ¹⁸F‐labeled radiotracers fall below 2 Ci μmol⁻¹, yet ¹⁸F‐aryltrifluoroborate synthesis affords specific activities as high as 15 Ci μmol⁻¹. This has been confirmed by using click chemistry to link an [¹⁸F]‐ArBF₃⁻ to rhodamine and thereby demonstrating a rapid and generalizable one‐pot method for preparing a fluorescent tracer with about 10‐fold higher specific activity than usual.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1xm2h272" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>