A Concise Total Synthesis of (R)‐Puraquinonic Acid1. Issue 12 (18th February 2013)

• Record Type: Journal Article
• Authors: Tiong, Erica A.; Rivalti, Daniel; Williams, Benjamin M.; Gleason, James L.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 12(2013)
• Page Start: 3442
• Page End: 3445
• Publication Date: 2013-02-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201208792
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Distant relative:</bold> The configuration of the quaternary stereocenter in puraquinonic acid (see scheme, right) is defined by groups far removed from the point of asymmetry. The use of a bicyclic thioglycolate lactam to set the quaternary stereocenter at an early stage cuts the length of the synthesis of the natural product by nearly two thirds.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1v78m425" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>