Polymer Nanofiber‐Embedded Microchips for Detection, Isolation, and Molecular Analysis of Single Circulating Melanoma Cells1. Issue 12 (21st February 2013)

• Record Type: Journal Article
• Authors: Hou, Shuang; Zhao, Libo; Shen, Qinglin; Yu, Juehua; Ng, Charles; Kong, Xiangju; Wu, Dongxia; Song, Min; Shi, Xiaohong; Xu, Xiaochun; OuYang, Wei‐Han; He, Rongxian; Zhao, Xing‐Zhong; Lee, Tom; Brunicardi, F. Charles; Garcia, Mitch André; Ribas, Antoni; Lo, Roger S.; Tseng, Hsian‐Rong
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 12(2013)
• Page Start: 3379
• Page End: 3383
• Publication Date: 2013-02-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201208452
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Confined to one cell</bold>: A method to detect and isolate single circulating melanoma cells (CMCs; see figure) has been produced by integrating a polymer‐nanofiber‐embedded nanovelcro cell‐affinity assay with a laser microdissection (LMD) technique. This method is able to separate CMCs from normal white blood cells (WBCs) and sequence individual cells for a specific mutation related to cancer progression, allowing for more personalized cancer therapy.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1v78m5kz" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>