Structures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe4S4] Protein IspH1. Issue 7 (10th January 2013)

• Record Type: Journal Article
• Authors: Span, Ingrid; Wang, Ke; Wang, Weixue; Jauch, Johann; Eisenreich, Wolfgang; Bacher, Adelbert; Oldfield, Eric; Groll, Michael
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 7(2013)
• Page Start: 2118
• Page End: 2121
• Publication Date: 2013-01-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201208469
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The iron–sulfur protein IspH</bold> catalyzes a key step in isoprenoid biosynthesis in bacteria and malaria parasites. Crystal structures of IspH complexed with three substrate analogues reveal their mode of binding and suggest new routes to inhibitor design.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1v4b0sdg" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>