Enantioselective Nickel‐Catalyzed Hydrocyanation of Vinylarenes Using Chiral Phosphine–Phosphite Ligands and TMS‐CN as a Source of HCN1. Issue 5 (20th December 2012)

• Record Type: Journal Article
• Authors: Falk, Anna; Göderz, Anna‐Lena; Schmalz, Hans‐Günther
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 5(2013)
• Page Start: 1576
• Page End: 1580
• Publication Date: 2012-12-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201208082
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Anti‐headache chemistry</bold>: In the presence of a tailored modular P, P ligand the nickel‐catalyzed addition of HCN, generated in situ from TMS‐CN, to styrene derivatives proceeds with an unprecedented level of stereocontrol (up to 97 % <italic>ee</italic>) to give 2‐aryl‐acetonitriles, for example, the depicted precursor of Ibuprofen.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1p8rs362" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>