Copper‐Catalyzed Hydrodefluorination of Fluoroarenes by Copper Hydride Intermediates1. Issue 11 (10th February 2013)

• Record Type: Journal Article
• Authors: Lv, Hongbin; Cai, Yuan‐Bo; Zhang, Jun‐Long
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 11(2013)
• Page Start: 3203
• Page End: 3207
• Publication Date: 2013-02-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201208364
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Breaking bad</bold>: Efficient copper‐catalyzed CF bond activation has been achieved by replacing fluorine with hydrogen. A copper hydride is proposed as the active intermediate, which proceeds through a nucleophilic attack on the fluorocarbon, as determined by experimental and theoretical results (see structure; C gray, H white, Cu light red, F light blue; distances in Å).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1v8wsvvm" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>