Asymmetric Intramolecular Oxa‐Michael Reactions of Cyclohexadienones Catalyzed by a Primary Amine Salt1. Issue 6 (20th December 2012) - Wu, Wenbin
Abstract Michael brings the rings: An asymmetric intramolecular oxa‐Michael reaction involving iminium activation has been developed. This reaction provides enantioenriched 1, 4‐dioxane derivatives with up to 99 % yield and 98 % ee. The method allows for concise and stereoselective access to stereodiverse, complex tetracyclic compounds containing a bicyclo[2.2.2]octan‐2‐one backbone with multiple chiral centers.