Functionalizing αvβ3‐ or α5β1‐Selective Integrin Antagonists for Surface Coating: A Method To Discriminate Integrin Subtypes In Vitro1. Issue 5 (12th December 2012)

• Record Type: Journal Article
• Authors: Rechenmacher, Florian; Neubauer, Stefanie; Polleux, Julien; Mas‐Moruno, Carlos; De Simone, Mariarosaria; Cavalcanti‐Adam, Elisabetta Ada; Spatz, Joachim P.; Fässler, Reinhard; Kessler, Horst
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 5(2013)
• Page Start: 1572
• Page End: 1575
• Publication Date: 2012-12-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201206370
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Stuck with the right choice</bold>: αvβ3‐ or α5β1‐selective integrin ligands were functionalized for surface coating without losing activity and selectivity. The coating of nanostructured gold surfaces with these compounds stimulated subtype‐selective cell adhesion of genetically modified αvβ3‐ or α5β1‐expressing fibroblasts in vitro.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1p8rs3t0" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>