Silicon‐Nanowire‐Based Nanocarriers with Ultrahigh Drug‐Loading Capacity for In Vitro and In Vivo Cancer Therapy1. Issue 5 (11th December 2012)

• Record Type: Journal Article
• Authors: Peng, Fei; Su, Yuanyuan; Wei, Xinpan; Lu, Yimei; Zhou, Yanfeng; Zhong, Yiling; Lee, Shuit‐Tong; He, Yao
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 5(2013)
• Page Start: 1457
• Page End: 1461
• Publication Date: 2012-12-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201206737
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A pratical agent for cancer therapy</bold>: Silicon nanowires (SiNWs) were employed in the design of high‐performance drug nanocarriers. The SiNWs were used as nanovectors for the delivery of an anticancer drug (DOX). SiNWs feature an ultrahigh drug‐loading capacity. In vitro and in vivo experiments show that SiNW‐based nanocarriers are highly efficacious for cancer therapy (see picture).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1p8rs207" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>