Blood‐Inert Surfaces via Ion‐Pair Anchoring of Zwitterionic Copolymer Brushes in Human Whole Blood. (28th September 2012)

• Record Type: Journal Article
• Authors: Chang, Yung; Shih, Yu‐Ju; Lai, Chia‐Jung; Kung, Hsiao‐Han; Jiang, Shaoyi
• Is Part Of: Advanced functional materials. Volume 23:Number 9(2013)
• Page Start: 1100
• Page End: 1110
• Publication Date: 2012-09-28
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201201386
• Languages: English
• ISSNs: 1616-301X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A strategy to create blood‐inert surfaces in human whole blood via ion‐pair anchoring of zwitterionic copolymer brushesand a systematic study of how well‐defined chain lengths and well‐controlled surface packing densities of zwitterionic polymers affect blood compatibility are reported. Well‐defined diblock copolymers, poly(11‐mercaptoundecyl sulfonic acid)‐<italic>block</italic>‐poly(sulfobetaine methacrylate) (PSA‐<italic>b</italic>‐PSBMA) with varying zwitterionic PSBMA or negatively charged PSA lengths, are synthesized via atom‐transfer radical polymerization (ATRP). PSA‐<italic>b</italic>‐PSBMA is grafted onto a surface covered with polycation brushes as a mimic polar/hydrophilic biomaterial surface via ion‐pair anchoring at a range of copolymer concentrations. Protein adsorption from single‐protein solutions, 100% blood serum, and 100% blood plasma onto the surfaces covered with PSA‐<italic>b</italic>‐PSBMA brushes is evaluated using a surface plasmon resonance sensor. Copolymer brushes containing a high amount of zwitterionic SBMA units are further challenged with human whole blood. Low protein‐fouling surfaces with >90% reduction with respect to uncoated surfaces are achieved with longer PSA blocks and higher concentrations of PSA‐<italic>b</italic>‐PSBMA copolymers using the ion‐pair anchoring approach. This work provides a platform to achieve the control of various surface parameters and a practical method to create blood‐inert surfaces in whole blood by grafting ionic‐zwitterionic copolymers to charged biomaterials via charge pairing.</p> </abstract>