Broad‐Spectrum Antimicrobial and Biofilm‐Disrupting Hydrogels: Stereocomplex‐Driven Supramolecular Assemblies1. Issue 2 (19th November 2012)

• Record Type: Journal Article
• Authors: Li, Yan; Fukushima, Kazuki; Coady, Daniel J.; Engler, Amanda C.; Liu, Shaoqiong; Huang, Yuan; Cho, John S.; Guo, Yi; Miller, Lloyd S.; Tan, Jeremy P. K.; Ee, Pui Lai Rachel; Fan, Weimin; Yang, Yi Yan; Hedrick, James L.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 2(2013)
• Page Start: 674
• Page End: 678
• Publication Date: 2012-11-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201206053
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Fighting the resistance</bold>: Biodegradable and injectable/moldable hydrogels with hierarchical nanostructures (see picture) were made with broad‐spectrum antimicrobial activities and biofilm‐disruption capability. They demonstrate no cytotoxicity in vitro, and show excellent skin biocompatibility in animals. These hydrogels have great potential for clinical use in prevention and treatment of various multidrug‐resistant infections.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1p994sn0" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>