Protein Surface and Core Dynamics Show Concerted Hydration‐Dependent Activation1. Issue 2 (14th November 2012)

• Record Type: Journal Article
• Authors: Wood, Kathleen; Gallat, François‐Xavier; Otten, Renee; van Heel, Auke J.; Lethier, Mathilde; van Eijck, Lambert; Moulin, Martine; Haertlein, Michael; Weik, Martin; Mulder, Frans A. A.
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 2(2013)
• Page Start: 665
• Page End: 668
• Publication Date: 2012-11-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201205898
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>By specifically labeling</bold> leucine/valine methyl groups and lysine side chains "inside" and "outside" dynamics of proteins on the nanosecond timescale are compared using neutron scattering (see picture). Surprisingly, both groups display similar dynamics as a function of temperature, and the buried hydrophobic core is sensitive to hydration and undergoes a dynamical transition.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1p994mvq" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>