Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water1. Issue 8 (21st January 2013)

• Record Type: Journal Article
• Authors: Staudt, Svenja; Burda, Edyta; Giese, Carolin; Müller, Christina A.; Marienhagen, Jan; Schwaneberg, Ulrich; Hummel, Werner; Drauz, Karlheinz; Gröger, Harald
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 8(2013)
• Page Start: 2359
• Page End: 2363
• Publication Date: 2013-01-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201204464
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>It doesn′t take much</bold> to oxidize cycloalkanes directly to the corresponding cyclic ketones: molecular oxygen as the oxidant, water as the solvent, the cofactor NADP⁺ (and a little 2‐propanol to reduce it), as well as two catalytic enzymes—a hydroxylating P450 monooxygenase and an alcohol dehydrogenase (see scheme).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1xm2gzds" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>