Posttransfusion platelet increments after different platelet products in neonates: a retrospective cohort study. Issue 12 (26th February 2013)

• Record Type: Journal Article
• Authors: Honohan, Áine; van't, Ella; Hulzebos, Christian; Lopriore, Enrico; van't, Ellen; Govaert, Paul; Brand, Anneke; van der, Johanna
• Is Part Of: Transfusion. Volume 53:Issue 12(2013)
• Page Start: 3100
• Page End: 3109
• Publication Date: 2013-02-26
• Subjects: Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; Blood Group Antigens -- Periodicals; Blood Preservation -- Periodicals; Blood Transfusion -- Periodicals; 615
• DOI: 10.1111/trf.12127
• Languages: English
• ISSNs: 0041-1132

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="trf12127-sec-0001" sec-type="section"> <title>Background</title> <p>In the Netherlands different platelet (PLT) products are used for neonatal transfusions: volume‐reduced PLTs, PLT additive solution (PAS) II PLTs, and plasma PLTs. These are standard products at three different neonatal intensive care units where local transfusion guidelines apply. Here we assess the posttransfusion count increments with these products.</p> </sec> <sec id="trf12127-sec-0002" sec-type="section"> <title>Study Design and Methods</title> <p>We performed a retrospective cohort study of neonates who received, in the first month after birth, between January 1, 2007, and December 31, 2008, at least one PLT transfusion. Seventy‐four neonates who received 197 volume‐reduced PLTs transfusions, 68 neonates who received 105 PASII PLT transfusions, and eight neonates who received eight plasma PLT transfusions were analyzed. Early (within 8 hr after transfusion) and follow‐up count increments (16‐24 hr after transfusion) were evaluated for 191 and 81 volume‐reduced PLTs, 77 and 56 PASII PLTs, and six and five plasma PLT transfusions, respectively, using a random‐effects model.</p> </sec> <sec id="trf12127-sec-0003" sec-type="section"> <title>Results</title> <p>Volume‐reduced PLTs were transfused at twice the dose in one‐fifth the volume of PASII and plasma PLTs. The early posttransfusion count increment was higher for volume‐reduced PLTs at 111 × 10<sup>9</sup>/L (95% confidence interval [CI], 86‐135) compared to PASII PLTs at 62 × 10<sup>9</sup>/L (95% CI, 40‐84; p = 0.000) and plasma PLTs at 47 × 10<sup>9</sup>/L (95% CI, 14‐79). The follow‐up count increment was also higher for volume‐reduced PLTs at 60 × 10<sup>9</sup>/L (95% CI, 19‐100) compared to PASII PLTs at 38 × 10<sup>9</sup>/L (95% CI, −0.2 to 77; p = 0.082) and plasma PLTs at 4 × 10<sup>9</sup>/L (95% CI, −38 to 46).</p> </sec> <sec id="trf12127-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Neonates who received twice the PLT dose by volume‐reduced PLTs had twice as high early and follow‐up count increment showing similar efficacy of products.</p> </sec> </abstract>