Alterations of angiopoietin‐related growth factor (Angptl6) during pregnancy and in pre‐eclampsia. Issue 6 (30th May 2013)

• Record Type: Journal Article
• Authors: Xia, Guiyu; Fang, Ming; He, Yao; Zhang, Tao; Jin, Yangyang; Jiang, Lingxiang
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 39:Issue 6(2013:Jun.)
• Page Start: 1137
• Page End: 1141
• Publication Date: 2013-05-30
• Subjects: Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.12039
• Languages: English
• ISSNs: 1341-8076

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jog12039-sec-0001" sec-type="section"> <title>Aim</title> <p>The aim of this study was to clarify the alterations of angiopoietin‐related growth factor (AGF, also known as Angptl6/ARP5) in the serum of normally pregnant women and pre‐eclamptic women and to explore the role of AGF in pre‐eclampsia.</p> </sec> <sec id="jog12039-sec-0002" sec-type="section"> <title>Material and Methods</title> <p>Thirty healthy non‐pregnant women, 118 normally pregnant women (30 at 6–12 gestational weeks, 30 at 13–28 weeks and 58 at 29–40 weeks, respectively) and 46 pre‐eclamptic women were recruited. Fasting blood samples were obtained from all subjects. Fifteen women of healthy pregnant women provided their blood samples at 24 and 48 h after cesarean section, respectively. Enzyme‐linked immunosorbent assay was used to determine the serum level of AGF.</p> </sec> <sec id="jog12039-sec-0003" sec-type="section"> <title>Results</title> <p>Serum levels of AGF were significantly higher in normally pregnant women than non‐pregnant women (<italic>P</italic> < 0.001 of all). Although serum AGF of the first trimester was significantly higher than that of the second trimester (<italic>P</italic> = 0.033), there were no significant differences of serum AGF in the comparison between the first and third trimester (<italic>P</italic> = 0.064) and between the second and third trimester (<italic>P</italic> = 0.546). Serum AGF significantly decreased after delivery (<italic>P</italic> < 0.05). There were no significant differences in AGF of maternal serum between pre‐eclamptic women and normally pregnant control women (<italic>P</italic> = 0.285). There were no significant differences in circulating AGF concentration between non‐pregnant women and postpartum groups (<italic>P</italic> = 0.052 for 24 h after delivery and <italic>P</italic> = 0.083 for 48 h after delivery).</p> </sec> <sec id="jog12039-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The serum level of AGF was elevated in normal pregnancy compared with non‐pregnant women, suggesting that placenta is an important source of circulating AGF during pregnancy.</p> </sec> </abstract>