Effect of eicosapentaenoic acid agent on aggravated hypertriglyceridemia during pregnancy. Issue 11 (15th July 2013)

• Record Type: Journal Article
• Authors: Sato, Shimpei; Ohkuchi, Akihide; Kawano, Mikihiko; Iwanaga, Naoko; Furukawa, Yuichi; Matsumoto, Harunobu
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 39:Issue 11(2013:Nov.)
• Page Start: 1541
• Page End: 1544
• Publication Date: 2013-07-15
• Subjects: Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.12095
• Languages: English
• ISSNs: 1341-8076

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Aggravated hypertriglyceridemia with a serum triglyceride of more than 1000 mg/dL is a risk of acute pancreatitis during pregnancy. However, there have been few reports on the administration of an eicosapentaenoic acid (EPA) agent for aggravated hypertriglyceridemia during pregnancy. A 29‐year‐old multiparous Japanese woman was transferred to our hospital at 29 + 0 weeks of gestation due to hypertriglyceridemia of 898 mg/dL. Because diet control was not enough, we decided to use an EPA agent, resulting in a reduction in triglyceride levels to 550 mg/dL. A male infant, weighing 2667 g, was born at 37 + 2 weeks transabdominally, and was complicated with respiratory distress syndrome. The final diagnosis was type III hyperlipoproteinemia with the apolipoprotein E3/2 phenotype and a broad β‐migrating lipoprotein on polyacrylamide gel electrophoresis of serum lipoproteins. In conclusion, an EPA agent may be a possible therapeutic approach for aggravated hypertriglyceridemia during pregnancy, although it may increase a risk of respiratory distress syndrome.</p> </abstract>