Gold Nanodots: In vivo Metabolic Imaging of Insulin with Multiphoton Fluorescence of Human Insulin–Au Nanodots (Small 12/2013). Issue 12 (14th June 2013)

• Record Type: Journal Article
• Authors: Liu, Chien‐Liang; Liu, Tzu‐Ming; Hsieh, Tsung‐Yuan; Liu, Han‐Wen; Chen, Yu‐Shing; Tsai, Cheng‐Kun; Chen, Hsieh‐Chih; Lin, Jong‐Wei; Hsu, Ron‐Bin; Wang, Tzung‐Dau; Chen, Chien‐Cheng; Sun, Chi‐Kuang; Chou, Pi‐Tai
• Is Part Of: Small. Volume 9:Issue 12(2013:Jun.)
• Page Start: 2102
• Page End: 2102
• Publication Date: 2013-06-14
• Subjects: Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201370071
• Languages: English
• ISSNs: 1613-6810

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>In vivo imaging of insulin metabolism is realized by T.‐M. Liu, P.‐T. Chou and co‐workers using synthesized human insulin–Au nanodots (NDs). Benefiting from its efficient red to near infrared emission, deep tissue subcellular uptake of insulin–Au NDs can be evaluated with a nonlinear optical microscope. <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">On page 2103</ext-link>, insulin‐Au NDs permeate into lipid droplets (LDs) of adipocytes, and enlarged ones in type II diabetes mice have a higher adjacent/LD concentration contrast. Human clinical samples show similar trends in patients with diabetes and coronary artery diseas <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg224zp50w" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>