Bioinspired Patterning with Extreme Wettability Contrast on TiO2 Nanotube Array Surface: A Versatile Platform for Biomedical Applications. Issue 17 (18th February 2013)

• Record Type: Journal Article
• Authors: Lai, Yuekun; Lin, Longxiang; Pan, Fei; Huang, Jianying; Song, Ran; Huang, Yongxia; Lin, Changjian; Fuchs, Harald; Chi, Lifeng
• Is Part Of: Small. Volume 9:Issue 17(2013:Sep.)
• Page Start: 2945
• Page End: 2953
• Publication Date: 2013-02-18
• Subjects: Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201300187
• Languages: English
• ISSNs: 1613-6810

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Binary wettability patterned surfaces with extremely high wetting contrasts can be found in nature on living creatures. They offer a versatile platform for microfluidic management. In this work, a facile approach to fabricating erasable and rewritable surface patterns with extreme wettability contrasts (superhydrophilic/superhydrophobic) on a TiO₂ nanotube array (TNA) surface through self‐assembly and photocatalytic lithography is reported. The multifunctional micropatterned superhydrophobic TNA surface can act as a 2D scaffold for site‐selective cell immobilization and reversible protein absorption. Most importantly, such a high‐contrast wettability template can be used to construct various well‐defined 3D functional patterns, such as calcium phosphate, silver nanoparticles, drugs, and biomolecules in a highly selective manner. The 3D functional patterns would be a versatile platform in a wide range of applications, especial for biomedical devices (e.g., high‐throughput molecular sensing, targeted antibacterials, and drug delivery). In a proof‐of‐concept study, the surface‐enhanced Raman scattering and antibacterial performance of the fabricated 3D AgNP@TNA pattern, and the targeted drug delivery for site‐specific and high‐sensitivity cancer cell assays was investigated.</p> </abstract>