An Assessment of the Impact of SiO2 Nanoparticles of Different Sizes on the Rest/Wake Behavior and the Developmental Profile of Zebrafish Larvae. Issue 18 (7th March 2013)

• Record Type: Journal Article
• Authors: Xue, Ji‐Yang; Li, Xiang; Sun, Ming‐Zhu; Wang, Ya‐Ping; Wu, Ming; Zhang, Chun‐Yang; Wang, Ya‐Nan; Liu, Bo; Zhang, Yao‐Shu; Zhao, Xin; Feng, Xi‐Zeng
• Is Part Of: Small. Volume 9:Issue 18(2013:Sep.)
• Page Start: 3161
• Page End: 3168
• Publication Date: 2013-03-07
• Subjects: Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201300430
• Languages: English
• ISSNs: 1613-6810

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>In this study, zebrafish larvae are introduced as an in vivo platform to examine the neurotoxicity and developmental toxicity associated with continuous exposure to a concentration gradient of different sizes of SiO₂ nanoparticles (15 nm and 50 nm diameter) to determine the dose effect and size effect of SiO₂ nanoparticle (NP)‐induced toxicity. Bovine serum albumin (BSA‐V) is utilized as a stabilizing agent to prevent coagulation of the SiO₂ nanoparticles. To the best of our knowledge, this study is the first to describe locomotor activity assays linking rest/wake behavioral profiles for the purpose of investigating the neurotoxicity of NPs. In addition, developmental toxicological endpoints including mortality, LC₅₀, malformation, and cartilaginous deformity are assessed. The results show a concentration‐dependent increase in behavioral neurotoxicity, mortality, and malformation among larvae treated with the SiO₂ nanoparticles of 15 nm and 50 nm. A comparison of the 15 nm and 50 nm NPs by K‐means clustering analysis demonstrates that the 15 nm NPs have a greater neurotoxic effect than the 50 nm NPs, with the 50 nm NPs exhibiting greater developmental toxicity on the zebrafish larvae than the 15 nm NPs.</p> </abstract>