Characteristics and outcome of pediatric non‐hodgkin lymphoma patients with ovarian infiltration at presentation. Issue 12 (19th July 2013)

• Record Type: Journal Article
• Authors: van Dorp, Wendy; Owusuaa, Catherine; Laven, Joop S.E.; van den Heuvel‐Eibrink, Marry M.; Beishuizen, Auke
• Is Part Of: Pediatric blood & cancer. Volume 60:Issue 12(2013:Dec.)
• Page Start: 2054
• Page End: 2059
• Publication Date: 2013-07-19
• Subjects: Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.24582
• Languages: English
• ISSNs: 1545-5009

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="pbc24582-sec-0001" sec-type="section"> <title>Background</title> <p>Ovarian infiltration in pediatric non‐Hodgkin lymphoma (NHL) at presentation is rare and information on outcome is scarce and mainly based on case reports and small series.</p> </sec> <sec id="pbc24582-sec-0002" sec-type="section"> <title>Procedure</title> <p>Evaluation of clinical characteristics and outcome of ovarian infiltrated pediatric NHL cases of a single center, and an extensive review of the all cases reported so far in literature.</p> </sec> <sec id="pbc24582-sec-0003" sec-type="section"> <title>Results</title> <p>At presentation, 6/60 female NHL cases of our center had ovarian infiltration, and combining these cases with earlier case reports, a total of 42 cases were identified. Median age at presentation was 10.9 years (range 0–18), and all but one had a B‐cell immunophenotype, with 32/42 cases being classified as Burkitt. Bilateral involvement was reported in 26/41 cases, of which 22 were bilaterally ovariectomized as first treatment. All cases were treated with chemotherapy. Relapses were reported in 9/36 and death in 16/36. After follow‐up in our center (median 13.4 years), in 2 cases anti‐Müllerian hormone (AMH) values were available (2.1 and 0.9 µg/L), in non‐ovarian cases median 2.2 µg/L.</p> </sec> <sec id="pbc24582-sec-0004" sec-type="section"> <title>Conclusions</title> <p>We conclude that in case of ovarian tumors with negative markers, NHL should be considered in order to avoid unnecessary surgery. Pediatr Blood Cancer 2013;60:2054–2059. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>