Association between baseline fetal hemoglobin levels and incidence of severe vaso‐occlusive pain episodes in children with sickle cell anemia. Issue 10 (15th May 2013)

• Record Type: Journal Article
• Authors: Bhatnagar, Pallav; Keefer, Jeffrey R.; Casella, James F.; Barron‐Casella, Emily A.; Bean, Christopher J.; Hooper, Craig W.; Payne, Amanda B.; Arking, Dan E.; Debaun, Michael R.
• Is Part Of: Pediatric blood & cancer. Volume 60:Issue 10(2013:Oct.)
• Page Start: E125
• Page End: E127
• Publication Date: 2013-05-15
• Subjects: Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.24588
• Languages: English
• ISSNs: 1545-5009

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="pbc24588-sec-0001" sec-type="section"> <p>The ameliorating effect of high fetal hemoglobin (HbF) levels on the incidence of pain episodes in sickle cell anemia (SCA) is well‐known; however, in children this relationship is less clearly established. We hypothesized that higher HbF levels in children with SCA are associated with fewer severe pain episodes. A meta‐analysis of data from the Silent Infarct Transfusion Trial (n = 456) and the Cooperative Study of Sickle Cell Disease (n = 764), demonstrated that baseline HbF levels were associated with the incidence of severe pain, commonly defined across studies as an event requiring hospitalization (<italic>P</italic>‐value = 0.02). Pediatr Blood Cancer 2013;60:E125–E127. © 2013 Wiley Periodicals, Inc.<xref ref-type="link" rid="pbc24588-note-0005">2</xref></p> </sec> </abstract>